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Objective:To examine the effect of sildenafil (Viagra) on the blood pressure (BP) response in men with erectile dysfunction (ED) treated with sildenafil.

Method:The study included 696 patients with ED treated with sildenafil and 536 men without ED who were included in the study. BP was measured at the beginning of the ED treatment and at 6 and 12 months after therapy, and at follow-up.

Results:Of the 696 patients, 855 (77.9%) took sildenafil; 751 (59.3%) took sildenafil and 446 (31.3%) took sildenafil and 536 (33.3%) took sildenafil. The mean age of the patients was 48.7 ± 13.1 years.

Conclusions:A significant increase in mean systolic BP was noted in sildenafil and sildenafil-treated ED patients. This may indicate a possible positive effect on BP regulation and possibly may also be related to the treatment itself.

Viagra (sildenafil) - effect on blood pressure in men with erectile dysfunction (ED) treated with sildenafil.

ABSTRACT

The use of sildenafil, a phosphodiesterase type 5 inhibitor, has been associated with an increased risk of cardiovascular disease. In patients with ED, sildenafil may prevent exercise-induced pulmonary vasoconstriction and vasodilation that may be responsible for cardiovascular events. It also increases the sensitivity of the endothelium to nitric oxide. However, the effects of sildenafil on blood pressure in patients with ED remain controversial. Several randomized, controlled, double-blind, placebo-controlled trials have been performed on sildenafil and the effects of sildenafil on blood pressure in ED, including a pilot study that was terminated prematurely after one year. In this pilot study, sildenafil was studied in 473 patients with ED who were treated with sildenafil. The study showed a significant decrease in supine BP (mean: -0.6 mmHg; -0.9 to -0.6 mmHg; -1.4 to -0.6 mmHg; -0.9 to -0.9 mmHg) and an increase in supine systolic BP (mean: -1.0 mmHg; -1.0 to -1.2 mmHg; -0.7 to -1.8 mmHg; -1.4 to -1.5 mmHg; -0.7 to -0.9 mmHg; -0.9 to -0.9 mmHg; -0.9 to -1.0 mmHg; -0.7 to -0.9 mmHg) when compared to patients without ED. The change in supine systolic BP was not statistically significant.

Keywords:erectile dysfunction, blood pressure, phosphodiesterase type 5, sildenafil

Citation:Miguel A, Cipriani F, Cibotta A (2020) The effect of sildenafil (Viagra) on the blood pressure response in men with erectile dysfunction treated with sildenafil.

Copyright:© 2020 MIGuelA. All rights reserved.

erectile dysfunction, blood pressure, sildenafil, Viagra, sildenafil, PDE5 inhibitors, PDE5 inhibitors

Updated:26 Mar 2020

MiguelA, CibottaA, et al. (2020) The effect of sildenafil (Viagra) on the blood pressure response in men with erectile dysfunction treated with sildenafil.

What is a Sildenafil Citrate?

Sildenafil Citrate is an FDA-approved medication used to treat Erectile Dysfunction. It is a generic version of the medication Viagra.

How does Sildenafil Citrate work?

Sildenafil Citrate works by increasing blood flow to the penis, helping men with erectile dysfunction achieve and maintain an erection. It can also be used in other areas of the body, such as the back of the head or arms.

Who is Sildenafil Citrate used for?

Sildenafil Citrate is used to treat erectile dysfunction in men. It is often prescribed to men with ED or Erectile Dysfunction. It is also used in pulmonary arterial hypertension (PAH) to help improve blood flow to the penis.

What are the benefits of taking Sildenafil Citrate?

While it's important to take Sildenafil Citrate as prescribed, there are several other benefits that can come into play.

Improved Sexual Performance:

The increased blood flow to the penis can help men achieve and sustain an erection when sexually stimulated. This can help them have a better sex life, making it more likely for a partner to enjoy sex.

Better Sexual Health:

Sildenafil Citrate can help improve the overall health of a man's sex life, which can be especially important for women, as they may experience increased sexual desire and sensitivity.

Lower Anxiety:

The increased blood flow to the penis can reduce anxiety and help men with ED and ED symptoms improve. This can improve sexual function and overall health.

Increased Sex Drive:

Sildenafil Citrate can help improve sexual function in men. This can help men feel more satisfied and stimulated while having sex. This can help them enjoy a more fulfilling sex life.

How to take Sildenafil Citrate?

The recommended starting dose of Sildenafil Citrate is 50 mg. It can be taken with or without food. Your doctor may increase your dose to 100 mg or decrease to 25 mg, depending on your response to the medication.

How long does Sildenafil Citrate take to work?

The effects of Sildenafil Citrate can be felt within 15 to 30 minutes after taking the medication. However, it may take several hours to feel the full effects, so be sure to take your medication exactly as directed. If you have any questions or concerns, reach out to your doctor or pharmacist for guidance.

What to expect after taking Sildenafil Citrate?

As with any medication, there are some potential side effects that may occur if you do not take the medication properly. These can include:

  • Headache
  • Indigestion
  • Back pain
  • Muscle aches
  • Facial flushing
  • Dizziness
  • Nasal congestion
  • Insomnia
  • Trouble sleeping
  • Flushing

More serious side effects, such as allergic reactions or allergic disorders, may occur, which require immediate medical attention.

If you experience any severe side effects, it is important to contact your healthcare provider immediately. They may suggest that you stop taking Sildenafil Citrate and seek medical advice.

If you have any questions or concerns about the side effects of Sildenafil Citrate, don’t hesitate to reach out to your doctor or pharmacist for guidance.

References

Disclaimer

This article is for informational purposes only and does not constitute medical advice. It is not a substitute for your doctor's medical advice about treating your medical condition.

FDA-Approved Drugs

What is Sildenafil Citrate?

Sildenafil Citrate is an FDA-approved medication used to treat erectile dysfunction (ED) in men.

The Federal Court of Appeal, in a decision on the appeal of Eli Lilly and Company, reversed a trial judge’s judgment in a case that involved erectile dysfunction drugs, but had not decided the case.

The trial judge, who is also a member of the Federal Court of Appeal, found that the drug, Viagra, was not the product of a fraudulent application or marketing, but was based on a “personal judgment and medical necessity”. The judgment was upheld on appeal, but the Federal Court of Appeal has decided the appeal to be for a decision of the Federal Court of Appeal.

The Federal Court of Appeal has decided that Eli Lilly’s product, Viagra, was not a controlled substance under the Federal Food, Drug, and Cosmetic Act (FDCA), which means it is not “a medical device” under the FDCA. The decision is being appealed by the company that has filed the appeal, Eli Lilly.

On February 1, 2003, a jury found that the company had engaged in a “fraudulent marketing” scheme in which it promoted Viagra and its generic competitors, Cialis, Levitra and Cialis XR, without the knowledge of its U. S. customers, the company was forced to pay more than $1 billion to the U. government for a number of erectile dysfunction medications. The jury found that the drug was “a controlled substance under the FDCA, which was, in part, an illegal act”, and that the scheme took place “with the intent to promote the illegal nature of the drugs.”

The case was tried on February 6 and 10, 2003, by Judge William J. Weinstein of the U. District Court for the District of New Jersey.

The case was before the Federal Court of Appeal in March 2003, which affirmed the judgment of the U. District Court in Eli Lilly, and ordered the decision of the Federal Court of Appeal be affirmed, finding that the defendant company failed to meet its burden of proving that the drugs were the result of an “off-label” advertising, marketing or distribution of the drugs. The case was tried before Judge William J. Weinstein, who was also a member of the Federal Court of Appeal’s panel, but he was dismissed from the case by the Federal Court of Appeal.

The case was consolidated with the case of GlaxoSmithKline PLC v. Lilly, the case in which the plaintiff’s complaint was brought against the defendant’s manufacturer for allegedly conspiring to market the erectile dysfunction drugs. The case was dismissed on appeal, but in February 2004, Judge Weinstein again dismissed the case.

In the decision, Judge Weinstein found that Eli Lilly failed to establish the required standard of proof that the products were intended by the plaintiff for use in interstate commerce, and that the conduct of the defendant company in marketing the erectile dysfunction drugs was so conduct that the plaintiff could not state a claim for damages.

In its order, the Federal Court of Appeal reversed the judgment of the Federal Court of Appeal, finding that the plaintiff’s complaint did not allege a “fraudulent intent” for marketing the erectile dysfunction drugs, and that the “plaintiff’s claim is without merit.”

In the case of Eli Lilly, the trial judge found that “[t]he plaintiff’s alleged fraudulent intent for marketing a drug was so likely to deceive the public that it was not a legitimate use of the drug in interstate commerce,” and that the defendant’s conduct was such a fraudulent scheme, that it was “clearly the tort of deceptive marketing”.

The trial judge concluded that the defendant company, Eli Lilly, failed to meet its burden of proof that the drug was intended for marketing. In the order, he also found that the defendant company failed to establish that the drugs were the result of an “off-label” advertising, marketing or distribution of the drugs. The case is being appealed by the company that has filed the appeal, Eli Lilly.

In the decision, the Federal Court of Appeal is bound by the decision of the trial judge in this case, but the decision is also being appealed to the Federal Court of Appeal, and the decision is being appealed to the Federal Court of Appeal.

The Federal Court of Appeal, on April 28, 2004, affirmed the judgment of the Federal Court of Appeal, holding that Eli Lilly was not liable for damages caused by the alleged fraudulent scheme.

Viagra Connect is a new erectile dysfunction treatment which does not require a prescription.

The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online without a trip to your doctor.

We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.

A pharmacist may need to contact you by phone before providing the product. If they cannot reach you within 72 hours, your order may be delayed, or this item may be cancelled from your order.

Please ensure your contact details are correct before ordering this medicine.Suitable forViagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex

Age RestrictionYou must be at least 18 years old to purchase this product.

Directions for use:Please read the enclosed leaflet carefully before use.

• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.

Hazards and Cautions

Do NOT take if you:

  • do not have an erection problem
  • take any nitrate medicine for chest pain or heart failure
  • take riociguat (or other guanylate cyclase stimulators) for high blood pressure in the lungs
  • take ritonavir for the treatment of HIV
  • have been advised by your doctor to avoid sexual activity because of a problem with your heart or blood vessels
  • have a severe heart or liver problem
  • have low blood pressure
  • have ever had severe vision loss or a rare inherited eye disease
  • have a deformed penis
  • have an allergy to any of the ingredients in this product

Talk to your pharmacist or doctor before taking if you:

  • get very breathless or feel chest pain with light or moderate physical activities
  • have a heart problem
  • have high blood pressure that is not controlled
  • take any other medicines listed in the package leaflet
  • take any other treatment for erectile dysfunction
  • ever had a persistent erection that lasted for more than 4 hours
  • have a stomach ulcer or bleeding disorder
  • have diagnosed mild to moderate liver problems
  • have diagnosed severe kidney problems

As with all medicines, please ensure you read the patient information leaflet before taking this item.

For severe heart problems. Viagra Connect may cause a severe allergic reaction, especially when taken at the first sign of an erection. If you notice any symptoms of a your health condition being worse, including sudden skin rash, get medical advice before taking this medicine.

As-is branded prescription only medicines. Viagra Connect requires a prescription from a approved pharmacy. These prescriptiontimes information for your order may be found below.Generic medicines are NOT eligible to buy in this product name order.